Monday, February 10, 2014
Leukemia Cures and Natural Treatments
Leukemia Cures and Natural Treatments
Are you looking for a fresh approach to leukemia cures? If so then you may want to know that there are natural leukemia cures available. Many people who have cancer find themselves looking for these cures simply because the traditional medical treatments for these illnesses take so much out of the patient physically.
This being said it is certainly not uncommon to find that many are looking for cures that don't make them as sick and don't leave them feeling completely and utterly drained.
Alternative natural treatment methods include detoxification and oxygenation that you could use to cure yourself of cancer. As for their loved ones, they may even be the ones that see it first and begin the search for a natural method because seeing their family member go through so much might simply be too much for them to handle, and they are not even the ones enduring them.
Why are natural treatments better?
Natural treatments have been proven to actually cure cancer just like the medical treatments have. The best part of these is as mentioned above the side effects are nothing in comparison to the side effects of the chemical treatments. Most of the natural remedies actually have no side effects at all. These might be what draw so many people to those natural treatments.
After all who would want to go through the nausea, vomit, fatigue, and hair loss, not to mention other side effects these chemical treatments can cause? Should you decide that you are in preference to the chemical treatments you should know that there are also some natural treatments that you might be able to use at the same time to help optimize your chances of remission.
This is not to say that all natural remedies work for all people because they simply don't. What it is saying is that there is a great chance of remission using natural methods as well though just like chemotherapy does not work for everyone you may find that a few of the natural remedies don't work for you either.
You may also find that you get the best results by using several different natural remedies at one time. This is the best way to optimize your results with natural treatment.
What are some natural treatment methods?
There are lots of natural treatment methods that you can use. As mentioned above you may even choose to use more than one treatment method at a time. This could be two or more natural methods or a chemical method with a natural method.
If you are undergoing any kind of treatment or taking any medications you will need to be sure to discuss these methods with your doctor before you start taking them. Even if you aren't going through treatment or medication it is still a good idea for this to be brought up.
You should never use a natural method without reporting it to your treating physician having a doctor over see you is still very important to your health and in getting the treatments that you need.
Many times your physician will not see problems in the natural methods of your choice if there should be a conflict however because of your current treatment or medication then your doctor should be able to tell you which natural methods you can use to get you going with the natural treatment that you desire.
Article Source: http://EzineArticles.com/?expert=Ty_Daniel
Article Source: http://EzineArticles.com/3549165
Wednesday, June 12, 2013
Glycoscience Leukemia Breakthrough
Glycoscience Leukemia Breakthrough
Scientists have found that leukemia cells have altered cell surface carbohydrates. This is a remarkable discovery and may change how cancer it treated.
When glycoprotein receptor sites on the surface of human cells become deformed, they can kill you. It is from these little antenna all communication is made to support life.
You have some 56 quintillion receptor sites (give or take a few trillion). Every single antenna is constructed from Smart Sugars.
When your body does not have enough Smart Sugars, it can manufacture them from glucose and other sugars present.
However, the enzymatic gymnastics require so much time and energy that the job is not finished properly. When the job is not finished, the receptors are deformed and malfunction with corrupted signals.
Researchers at Griffith University's Institute for Glycomics in Australia and The Saban Research Institute of Children's Hospital Los Angeles have discovered that leukaemic cells have altered cell surface carbohydrates compared to normal cells. Altered cell surface carbohydrates is a critical weakness in leukaemic cells. This knowledge may pave the way for new cancer treatments.
Professor Mark von Itzstein is Director of Griffith University's Institute for Glycomics and the Australian team leader.
He said the discovery is an important advance against leukemia, a cancer of malignant white blood cells that multiply uncontrollably.
Professors Nora Heisterkamp and John Groffen, leaders of the US-based team and Professor von Itzstein and their colleagues have published their research findings in the latest edition of the internationally acclaimed Journal of Experimental Medicine.
We know removal of healthy glycoproteins from the surface of healthy cells will kill healthy cell. So, the immediate response of the researchers is to remove the altered glycoproteins from the cancerous cells thereby killing the cell. Sounds good, but...
Could it be that the scientists are looking through the wrong end of the microscope? It seems more plausible to improve the immune system by making more healthy glycoprotein receptor sites instead of killing the unhealthy cells.
That is the job of the immune system. You may be able to do that with additional Smart Sugars in the body which will cut down on the time and energy required for enzymatic gymnastics to produce healthy receptor sites.
More research is needed to determine how beneficial certain sugars are to the human body. Glycoscience work world-wide will provide the information needed so the general public can determine for themselves how best to take control of their own health using Smart Sugars.
Article Source: http://EzineArticles.com/?expert=JC_Spencer
Article Source: http://EzineArticles.com/7584835
Thursday, December 20, 2012
What is Leukemia?
What is Leukemia?
Today, one of the most dangerous and incurable condition seems to be cancer. It has no actual cure for mostly of the tissues it affects, especially when it reaches vital organs such as heart, lungs or blood. The blood tissue form of cancer is known as Leukemia and it represents a real life threat as it affects the blood circulation meant to supply the whole body with vital nutriments.
Blood is the connection tissue for all of the body's organs and tissue as it carries oxygen and other important elements for the cell life. This is the reason why leukemia is such dangerous and frightening disease. Blood has access to all vital organs like heart, lungs and brain and when Leukemia occurs, it will rapidly create a dysfunction of all the other organs by supplying them with unhealthy particles. Cancerous cells are quickly carried to all parts of the organism and the dissemination occurs in a very short period of time.
What is Leukemia ?
Leukemia is in fact the consequence of an abnormality occurred in the form and number of leukocytes, the blood white cells. Leucocytes are vital for the good functioning of the body as they have the role to fight against all potential aggressions from the outside. They are the key to a good protection against infections and when leukemia appears the cellular immunity decreases drastically leaving the body unable to protect against damaging factors of any nature.
The main pathological way of the disease is an increased production by the marrow of infected and abnormal white blood cells. The new leucocytes anatomically and functionally modified and interfere with all functions of the blood even hindering the normal oxygen transport. Modified white blood cells also damage the normal functioning of the red blood cells and lead to the occurrence of anemia. Cancerous cells impede the tissue supply with hemoglobin and the body cells suffer from the lack of iron.
When the cancerous cells reach the brain, other dangerous modifications appear such as headaches, night sweats and neuropsychical problems. Cancerous Leukemia cells can be easily detected under the microscope and the suspects of the disease are advised to undergo a bone marrow examination. The onset of Leukemia is pointed out by swollen lymph nodes through the whole body, especially around the neck and thigh.
What is Leukemia ?
Risk factors for Leukemia are especially radioactive radiations that produce cell mutations and damages to their activity. An overexposure to benzene, an industrial hydrocarbure, also increases the risk of developing Leukemia, as well as the Down syndrome.
The most effective but also painful treatment is chemotherapy when the patients need to swallow many drugs at once. Another possibility of treatment is radiotherapy and patients suffer from losing hair and skin texture.
Leukemia is curable if detected in time and treated right. A bone marrow transplant may be helpful to regain healthy white blood cells. For a good outcome, the patients especially need the support of the family.
Article Source: http://EzineArticles.com/?expert=Groshan_Fabiola
Thursday, October 18, 2012
Learning To Live With A Leukemia Diagnosis
Learning To Live With A Leukemia Diagnosis
There are numerous symptoms of leukemia which you might notice after being diagnosed. Having said that, many people are not sure if they should be worried if they notice new symptoms.
It's generally recommended that you call your leukemia doctor when you notice things like frequent fevers, night sweats, as well as being tired for no reason and they persist for more than a couple of weeks.
Other issues you might notice happening for two weeks that should tell you to call your physician include swollen glands or new lumps in the neck, groin area, as well as under an arm.
If you notice you are starting to bruise quicker or start bleeding from your gums, then those are also signs.
Watchful waiting refers to a time period when a leukemia doctor regularly checks on a patient but is not doing anything to treat them. It can also be called surveillance as well as observation.
The point of the period is to figure out whether or not you will develop any symptoms. For older adults, it can be a choice for treatment.
During the period, medical and blood tests will be taken as well as scans during standard doctor appointments. In certain cases, watchful waiting can actually give better results than aggressive early stage treatment.
The truth is, many people that are suffering from chronic lymphocycic leukemia live for a reasonable amount of time with no treatment. When you are considering other leukemia types, watchful waiting will never be recommended.
Right after being diagnosed with leukemia, you may want to know who you can see about symptoms. Quite a few health professionals are capable, so you can go to any of them.
These people include nurse practitioners, family medicine physicians, physician assistants, internists, and also pediatricians. The leukemia doctor that will actually diagnose you will be a hematologist or a medical oncologist.
Dependent on the type of leukemia you could have, your choices can vary. Should you be dealing with chronic lymphocytic leukemia, you will likely go through a period known as watchful waiting.
In that time, the goal is usually to see what occurs with your symptoms. If you see things such as night sweats, frequent fevers, rapid weight loss, or swollen glands, you will need to call the doctor.
No matter whether you have currently been diagnosed with leukemia or you think you might have it, it's a good plan to find out who to see next.
For people who haven't been diagnosed, you will be referred to a specialist that will be able to conclusively detect whether or not you are dealing with it. These kind of professionals include medical oncologists and also hematologists.
Once you have been diagnosed, you will be able to get the help of others and won't be limited by just seeing a leukemia doctor. You'll be able to call a physician assistant, pediatrician, family medicine physician, or possibly a nurse in case you notice your signs and symptoms getting worse or lasting for over a couple of weeks.
Article Source: http://EzineArticles.com/?expert=Scott_Smoot
Article Source: http://EzineArticles.com/6322183
Friday, June 29, 2012
Morphology of Hairy Cell Leukemia
Morphology of Hairy Cell Leukemia
Accurate diagnosis of hairy cell leukemia rests upon the recognition of the cells in blood, bone marrow, or spleen.
Morphologic observation of these pathognomonic cells is more art than science.
This trenchant observation of Yam and colleagues is as relevant today as when it was written in 1972 and emphasizes that, despite the ever-growing battery of ancillary studies to assist the hematopathologist, the identification of cytologically characteristic cells remains the diagnostic sine qua non of HCL. Here we will spot the light on hairy cells in peripheral blood.
Hairy cells derive their name from the irregular fine cytoplasmic projections that extend for variable distances from the periphery. It is, however, a combination of characteristics that identifies the HC in Romanowsky preparations (e.g. Wright stain).
The eccentric nucleus with its fine chromatin condensation, the pale slate-blue cytoplasm and the fine surface projections all form part of the initial diagnostic impression.HC surface morphology is best appreciated by phase microscopy of a viable "wet" preparation of moving cells in suspension and here the typical villous nature of the HC are easily appreciated.
In Wright-stained preparations, the hairy cell is 1.5 to 2 times the size of a mature lymphocyte and the nucleus occupies one half to two thirds of the cell's area.
HCL tends to be a disease of monotonous cells with respect to cytologic characteristics and size. Hence, although there may be a moderate degree of cell size variation between patients, an individual patient usually displays a remarkably homogeneous population of hairy cells.
The nuclei can have several configurations, including round, oval, spindled, reniform, horseshoe-shaped, and bilobed. Although the hairy cells in an individual vary in nuclear contours, most patients have a preponderant nuclear shape, most commonly oval.
Despite variation in nuclear contour, there are several consistent nuclear characteristics of HCL that assist greatly in recognition.
Most important, the nuclear membrane is nearly always smooth, imparting a distinct demarcation from the surrounding cytoplasm and lacking the fine surface irregularities that typify many other lymphoproliferative disorders.
As well, the nuclear membrane usually appears thickened. The chromatin of HCL has a partially condensed appearance that is intermediate between a mature lymphocyte and a blast.
Additionally, the chromatin has a uniform granular appearance in contrast to the irregularly clumped chromatin of other disorders, particularly B-cell chronic lymphocytic leukemia (B-CLL) and splenic marginal zone lymphoma (SMZL).
Hairy cells have no evident nucleoli or a single nucleolus. Infrequently, cells with two nucleoli are present.
Generally, patients demonstrate a predominance of nucleolated or nonnucleolated cells.
The nucleoli are nearly always small, round, and without irregularities in contour.
Peripheral blood
The morphological presentation of HCL in the peripheral blood is variable. Some patients present with the appearance of leukaemic peripheral blood, including a moderate lymphocytosis composed of morphologically identifiable hairy cells.
In other cases, the peripheral blood smear is notable only for monocytopenia or neutropenia, with scant to absent circulating hairy cells.
Article Source: http://EzineArticles.com/?expert=Sayed_EL_Assal
Article Source: http://EzineArticles.com/3107148
Thursday, May 24, 2012
Types Of Acute Leukemia
Types Of Acute Leukemia
Leukemia is a disease of the bone marrow and blood that will affect our blood cell production. Normal blood cells have a limited life span and they need to be constantly replaced by fresh, young cells to resume their activity. There is a type of cell within the bone marrow (stem cell) that matures into the type of blood cells that the body needs.
In normal condition, these stem cells develop either into red blood cells, white blood cells or platelets, into a controlled way. Leukemia affects the normal development of blood cells and causes the accumulation of partially developed cells that are not able to fulfill their role inside the organism.
Judging by the speed of development and the persistence of the disorder, there are two types of leukemia:
i. Acute leukemia
ii. Chronic leukemia
Judging by the types of stem cells affected by the disorder, leukemia can either be:
i. Lymphocytic
ii. Myelogenous
Acute leukemia differs from chronic leukemia by the levels that stem cells are able to reach in their development (stem cells that present anomalies still manage to partially develop and either resemble immature cells or complete, normal white blood cells).
Inside the body of people who suffer from acute myelogenous leukemia, the bone marrow syntheses stem cells which form a kind of partially matured white blood cell called myeloblast. This form of blood cell does not reach a full maturity state and cannot carry out its intended role. Myelogenous cells tend to multiply very fast and exceed the numbers of healthy blood cells, facilitating the occurrence of anemia, infections and weakening the immune system of the body. The diseased cells can also spread to other places of the organism, such as organs.
As statistics indicate, there are lots of annual cases of the disease, acute leukemia of myelogenous form being the most basic type of leukemia. Although the disease is known to regress quickly when the appropriate treatment is administered, if left untreated it may cause the death of the affected person. This kind of leukemia tends to recidivate and it can redevelop with time.
Regardless of age and sex, many people are diagnosed with forms of leukemia. Children have respond better to some types of leukemia, while adults difficultly cope with the disease. The cases of acute leukemia exceed those of chronic leukemia by approximately 10 percent.
Older adults seem to be affected the most by acute leukemia. Around two thirds of acute leukemia cases seem to occur after the age of 60. Leukemia is a serious form of cancer and it needs immediate treatment. If treated correctly, especially in its incipient stages, leukemia can be successfully overcome.
By: Chen Siong
Article Directory: http://www.articledashboard.com
Thursday, March 8, 2012
Promyelocytic Leukemia
Promyelocytic Leukemia
Promyelocytic Leukemia a growth of the bone marrow in which there is a deficit of mature blood cells in the myeloid line of cells and a surplus of immature cells called promyelocytes. Promyelocytic leukemia is due to a translocation between chromosomes 15 and 17 which is symbolized t(15;17).
This translocation is not a mere indicator of promyelocytic leukemia but the main cause. Promyelocytic leukemia generally comes under the acute form leukemia. It is also termed as acute promyelocytic leukemia (APL).
In 1957, promyelocytic leukemia was first accepted as an individual disease entity. It accounts for 5-10% of cases of acute myeloid leukemia (AML). The peak incidence of promyelocytic leukemia is amongst young adults. Promyelocytic leukemia is thought of as a type of AML and is classified as the M3 variant of AML.
Symptoms of promyelocytic leukemia are generally nonspecific and comprise of fatigue, minor infections, or hemorrhagic diathesis. There is usually pancytopenia with anemia, low levels of the granulocytes and monocytes, and low levels of platelets. Transfusion is thus an alternative that can be availed of.
Treatment of promyelocytic leukemia is different from that for all other forms of AML. Majority patients are now treated with all-trans-retinoic acid (ATRA). ATRA is a form of "differentiation therapy." It activates the retinoid receptor RAR and causes the promyeloctes to mature and this deters them from proliferating.
Even though ATRA cannot eliminate the leukemic clone it can stimulate a complete diminution in most patients suffering from promyelocytic leukemia by causing the promyelocytic leukemia -blasts to mature. ATRA is therefore used in combination with chemotherapy including an anthracycline drug.
Chances of survival are better with the combination of ATRA and chemotherapy than chemotherapy alone. This is because ATRA combined with chemotherapy accounts for a slightly higher rate of complete remissions while allowing significantly fewer relapses.
Maintenance cure with ATRA, and possibly with low-dose chemotherapy, further reduces the occurrence of relapse. The advent of ATRA therapy has revolutionized the treatment of promyelocytic leukemia and clearly enhanced the prognosis.
Promyelocytic leukemia is connected with a characteristic cellular picture classified as M3 in the French-American-British Classification and responds positively to treatments including retinoids, chemotherapy and, most recently, arsenicals.
Leukemia provides detailed information on Leukemia, Leukemia Symptoms, Childhood Leukemia, Leukemia Treatments and more. Leukemia is affiliated with Social Security Disabilities.
Article Source: http://EzineArticles.com/?expert=Jennifer_Bailey
Article Source: http://EzineArticles.com/408883
Tuesday, September 20, 2011
Statistic Information on Leukemia
Statistic Information on Leukemia
Leukemia is a cancerous disease caused by abnormal activity of stem cells (immature cells that originate in the bone marrow). There are two main types of leukemia - myelogenous and lymphocytic (according to the type of cells involved), which can be further classified in two categories - acute and chronic.
Acute leukemia is characterized by the rapid multiplication of partially developed, functionless cells. These abnormal cells accumulate inside the bone marrow or in the blood stream, interfering with the activity of normal, healthy cells. People with acute leukemia also suffer from anemia, which is caused by a pronounced decrease in the number of red blood cells. Leukemia sufferers also have a deficit of healthy white cells, which have a vital role in fighting against infections. In addition, acute leukemia affects the body's production of platelets, which have an important role in blood coagulation (they speed up the healing of open wounds).
Chronic leukemia also causes serious impairments at cellular level, triggering an overproduction of abnormal cells. However, unlike acute leukemia, chronic forms of the disease allow the affected cells to reach more advanced stages of development. Thus, chronic leukemia has a slower rate of progression.
The annual prevalence of leukemia among the population of the United States is around 31.000 new cases. Leukemia has the highest incidence in older adults, commonly affecting people with ages over 60. However, there are certain types of leukemia that predominantly affect children. For instance, acute lymphocytic leukemia (ALL) is responsible for causing more than 80 percent of overall childhood leukemia cases.
In adults, the most common types of leukemia are acute myelogenous leukemia (AML) and chronic lymphocytic leukemia (CLL). Acute myelogenous leukemia accounts for more than 10.000 new cases each year, while chronic lymphocytic leukemia is responsible for causing around 8.000 new annual cases.
Leukemia has the highest incidence in the male gender. Statistics indicate that more than 56 percent of annual leukemia cases are diagnosed in men. Although it can be seen in all ethnical groups, leukemia predominantly affects Caucasian white people. The annual incidence of leukemia is lower in African Americans, while American Indians and Hispanics rarely develop the disease. Similarly, leukemia is rarely seen in Asian people.
The most common type of leukemia among children aged 3-15 is acute lymphocytic leukemia. Due to the fact that acute lymphocytic leukemia predominantly affects children, it is referred to as childhood leukemia. Childhood leukemia rarely affects children younger than 3 or with ages over 15. Despite the fact that modern medicine doesn't hold the cure for childhood leukemia, the medical treatments and therapies available nowadays can slow down the progression of the disease and in some cases, they can even overcome leukemia completely. The annual morbidity rate of leukemia among young patients has known a considerable decrease in the last two decades. Thanks to modern medical equipment, leukemia can be timely diagnosed, allowing prompt medical intervention. Nowadays, early diagnosis and new approaches in medical treatment can considerably extend patients' life-expectancy, thus increasing the chances of complete recovery.
Article Source: http://EzineArticles.com/?expert=Groshan_Fabiola
Article Source: http://EzineArticles.com/282987
Sunday, November 28, 2010
Leukemia and Children
Leukemia and Children
One of the most tragic of all forms of cancer is Leukemia, which each year kills thousands of children all over the planet. Leukemia is a disorder of the blood, the bone marrow, and the lymphatic system. as one would expect with a system of this size, complexity, and importance to the body, there are numerous ways that things can go wrong. Because of this, there are various types of leukemia, all with different areas of activity and effects on the body.
There are a few ways to breakdown which type of leukemia is being dealt with. There are divisions that could be made based on whether or not the patient is a child or adult, for example. But most commonly the division is made based on how the blood cells are effected, and where the abnormality is taking place.
With symptoms that mimic those of many other, milder illnesses, leukemia is a difficult disease to diagnose initially. Some of the symptoms one is likely to experience are pervasive feelings of fatigue, constant chills and night sweats, and susceptibility to infection. As you can see, these are all conditions that could come from something as mundane as being overworked and run down. Many people assume that's exactly what the problem is, and don't seek help until their condition becomes so bad that they are unable to perform normal everyday activities without extreme discomfort.
When a person does report to the doctor, a blood test or bone marrow test may be conducted. These are the only ways to reliably screen for leukemia. Because of the variousness of the symptoms, and the invasiveness of the screening methods, leukemia often goes undiagnosed, by some estimates in as many as 20% of all cases.
The classification of leukemia arises from a four-fold matrix of conditions. The first axis is that of acute vs. chronic. In the case of acute leukemia, large numbers of immature blood cells are rapidly released. Since they are not fully developed, they crowd out the productive cells, resulting in quick deterioration of health. In the chronic case, blood cells are more mature and build up more slowly, resulting in a gradual worsening of health.
The second axis of the matrix is that of lymphocytic vs. myelogenous. Lymphocytic leukemia effects the cells which make up the body's immune system. Myelogenous leukemia effects the myeloid cells, which are responsible for producing the range of blood cells-white, red, platelet-in the body. This matrix yields four distinct forms of the disease, all of which have different degrees of danger and populations within which they occur.
Unlike some other forms of cancer, leukemia is not primarily caused by any lifestyle choices. There is a strong genetic component, which can be exacerbated by exposure to radioactive compounds. If you have a history of leukemia in your family it is important to stay vigilant and aware of your health. There are different treatments available and the earlier you can diagnose the problem (especially with the acute leukemia) the more likely you can survive.
Article Source: http://EzineArticles.com/?expert=Vince_Armstrong
Friday, October 8, 2010
Dangers of Leukemia and Other Forms of Blood Cancers
Dangers of Leukemia and Other Forms of Blood Cancers
People suffering from leukemia suffer from one of the deadliest types of blood cancers. It is specifically, a form of cancer of the white blood cells.
In modern-day practice, leukemia can also refer to malignancy in the blood or any cellular element in the bone marrow, wherein, the white blood cells multiply uncontrollably. This results to more white blood cells in the bloodstream. This type of blood cancer usually occurs in children with ages between 3 to 7 years while in adults, it occurs between ages 50 to 60 years old.
The specific cause of leukemia is unknown but inheritance plays a big role in becoming susceptible to this condition. People with leukemia experience bone pain, easy bleeding, pale skin and fatigue as well as abdominal pain, easy bruising and lymph gland swelling. Treatment of leukemia includes radiation therapy, chemotherapy and bone marrow transplant.
Since blood cancers obviously involve the blood, it is more deadly and most dreaded. The infected blood can imminently spread to other parts of the body through the blood stream. Leukemia starts in the bone marrow - the spongy, soft material inside the bones where blood cells are produced from stem cells.
As mentioned above, leukemia mostly affects the white blood cells which protect the body against infection. Then, cancer commences when abnormal white blood cells are created as a result when the development of stem cells into white blood cells goes uncontrollably wrong. With blood cancers, the abnormal white cells take over other types of blood cells, including the red blood cells (the ones that transport oxygen to the body tissues) and the platelets which make blood clotting possible. Therefore, leukemia is the intervention of the blood's ability in carrying oxygen and in clotting.
Without the presence of leukemia, the white blood cells can readily function in fighting disease-producing germs or pathogens. However, when it becomes dysfunctional, it can weaken the patient's immune system.
The body won't be able to fight even the simplest of infections. Pathogens can start attacking various other bodily cells. Since blood cancers destroy the immune system's normal function, some patients can experience frequent infections ranging from infected tonsils, diarrhea or sores in the mouth to opportunistic infections and life-threatening pneumonia.
Studies are still ongoing as to determine the exact causes of leukemia. Medical experts think that exposure to ionizing radiations and hazardous chemicals can trigger the development of these blood cancers. Irrespective of the age, survival rate is very low. This enlists leukemia as one of the most fatal of all cancers.
Leukemia patients have a 43% survival rate of 5 years. It is also noted that leukemia is hereditary or it can be traced to the family's history. However, this should not hinder you from living a healthy lifestyle with regular exercise and nutritious diet to prevent it.
Diet should contain vegetable juices, lots of water, unrefined sea salt and foods that can heal like Aloe Vera, lemon, olive oil, green tea, tomato and more. For some people, fish, oranges and bananas can also help prevent blood cancers.
Article Source: http://EzineArticles.com/?expert=Annieson_Turner
Thursday, August 12, 2010
The Chronic and Acute Myelogenous Leukemia
The Chronic and Acute Myelogenous Leukemia
Acute myelogenous leukemia (AML), as well called acute nonlymphocytic leukemia (ANLL), is a rapidly progressive neoplasm resulting from hematopoietic precursors, or myeloid stem tissue, that give rise to granulocytes, monocytes, erythrocytes, and platelets. There's growing evidence that genetic events occurring early in stem mobile maturation can lead to leukemia. Very first, there's a lag time of 5-10 years towards the development of leukemia after coverage to known causative agents such as chemotherapy, radiation, and particular solvents.
2nd, many instances of secondary leukemia evolve out of a prolonged "preleukemic phase" manifested like a myelodysplastic syndrome of hypoproduction with abnormal maturation without having precise malignant behavior. Finally, examination of precursor cells at a stage earlier than the malignant expanded clone in a provided kind of leukemia can reveal genetic abnormalities such as monosomy or trisomy of various chromosomes. In maintaining using the general molecular theme of neoplasia, extra genetic modifications are witnessed in the malignant clone compared with the morphologically normal stem cell that developmentally precedes it.
Acute myelocytic leukemias are classified by morphology and cytochemical staining. Auer rods are crystalline cytoplasmic inclusion bodies characteristic of, though not uniformly witnessed in, all myeloid leukemias. In contrast to mature myeloid tissue, leukemic cells have large immature nuclei with open chromatin and prominent nucleoli. The look from the individual kinds of AML mirrors the cell kind from which they derive. M1 leukemias originate from early myeloid precursors with no apparent maturation toward any terminal myeloid mobile type. This really is apparent within the lack of granules or other features that mark more mature myeloid cells. M3 leukemias are a neoplasm of promyelocytes, precursors of granulocytes, and M3 cells exhibit abundant azurophilic granules which are common of normal promyelocytes.
M4 leukemias arise from myeloid precursors that may differentiate into granulocytes or monocytes, whereas M5 leukemias derive from precursors currently committed towards the monocyte lineage. Therefore, M4 and M5 cells both include the feature folded nucleus and gray cytoplasm of monocytes, whereas M4 cells include also granules of the granulocytic cytochemical staining pattern. M6 and M7 leukemias can't be readily identified on morphologic grounds, but immunostaining for erythrocytic proteins is positive in M6 tissue, and staining for platelet glycoproteins is apparent in M7 tissue.
Chromosomal deletions, duplications, and well balanced translocations had been noted about the leukemic tissue of some patients prior to the introduction of molecular genetic techniques. Cloning from the regions exactly where well balanced translocations occur has, in some cases, revealed a preserved translocation website that reproducibly fuses a single gene with an additional, producing in the manufacturing of a brand new blend protein. M3 leukemias show a really higher frequency of the t(15;17) translocation that juxtaposes the PML gene with the RAR- gene. RAR- encodes a retinoic acid steroid hormone receptor, and PML encodes a transcription factor whose target genes are unknown. The blend protein possesses novel biologic action that presumably results in improved proliferation and a obstruct of differentiation.
Interestingly, retinoic acid can induce a short-term remission of M3 leukemia, supporting the importance of the RAR--PML blend protein. Monosomy of chromosome seven can be observed in leukemias arising out from the preleukemic syndrome of myelodysplasia or in de novo leukemias, and in both instances this finding is associated with a worse clinical prognosis. This monosomy as well as other serial cytogenetic modifications may also be seen right after relapse of treated leukemia, a scenario characterized by a a lot more aggressive program and resistance to therapy.
As hematopoietic neoplasms, acute leukemias involve the bone marrow and usually manifest abnormal circulating leukemic (blast) cells. Occasionally, extramedullary leukemic infiltrates recognized as chloromas can be observed in other organs and mucosal surfaces. A marked improve within the number of circulating blasts can sometimes trigger vascular obstruction associated with hemorrhage and infarction within the cerebral and pulmonary vascular beds. This leukostasis results in symptoms such as strokes, retinal vein occlusion, and pulmonary infarction.
In most instances of AML along with other leukemias, peripheral blood counts of mature granulocytes, erythrocytes, and platelets are decreased. This is probably because of crowding from the bone marrow by blast tissue as nicely as the elaboration of inhibitory substances by leukemic cells or alteration of the bone marrow stromal microenvironment and cytokine milieu required for normal hematopoiesis. Susceptibility to infections consequently of depressed granulocyte amount and function and abnormal bleeding as a result of reduced platelet counts are common problems in sufferers initially presenting with leukemia.
Chronic myelogenous leukemia (CML) is an indolent leukemia manifested by an increased quantity of immature granulocytes in the marrow and peripheral circulation. One of the hallmarks of CML may be the Philadelphia chromosome, a cytogenetic function that is due to balanced translocation of chromosomes 9 and 22, producing in a fusion gene, bcr-abl, that encodes a kinase that phosphorylates a number of key proteins included in cell development and apoptosis. The fusion gene can recreate a CML-like syndrome when released into mice.
CML eventually transforms into acute leukemia (blast crisis), which is associated with further cytogenetic changes and a clinical course similar to that of acute leukemia. New courses of medicines that block the bcr-abl kinase by competing with the ATP-binding site, induce remissions in most patients in chronic phases of CML. Moreover, resistance to these bcr-abl inhibitors can include amplification from the bcr-abl breakpoint as nicely as the development (or clonal expansion) of mutations in the ATP-binding pocket of bcr-abl, which no longer allows binding of inhibitors.
Franco Zinzi has been involved with online marketing for nearly 3 years and likes to write on various subjects. Come visit his latest website which discusses of Mesothelioma Treatment Options and cancer related informations for the owner of his own life.
Article Source: http://EzineArticles.com/?expert=Franco_Zinzi
Thursday, July 8, 2010
General Info On Leukemia
General Info On Leukemia
Leukemia is a very serious disease that affects both the marrow and blood system. In the case of leukemia the number of white blood cells that are in a human body get seriously out of control and multiply to a very big and alarming number.
Because of this, and the fact that the marrow is responsible for normal blood production, the space for the normal count of blood cells to be made is messed up. From this 3 major problems occur: either the white blood cells become to rare the risk of infection seriously rising in this case, the red cells also become to be more rare, in this case anemia, fatigue or weakness affecting the patient.
Modern medicine has been able to classify leukemia in many types all of them with a wide variety of symptoms.
The word used to name this disorder also kind of names it: in Greek this literally means white blood. Because of the problems that occur in this disease the bone marrow might not be able to keep passe with the production of red blood cells or platelets in the normal numbers.
To make matters even worse the white cells start to increase in number at an alarming rate, thus not being capable to fully mature in order to fight viruses or other threats as they should. Aggravating the situation even more would be the fact that these great numbers of white cells infiltrate the organs causing even more problems like making them malfunction or even worse making them fail. The organs most likely to be affected are kidneys, liver and even the spleen. In the cases of the liver and spleen the size might actually increase.
The normal function of the spleen is that of a cleaner, filtering aging or dying red cells or platelets. When in the case of leukemia the spleen becomes enlarged, the duty that it has may actually become a problem for the body in the fact that it may actually start removing normally healthy red cells and platelets. This fact lids to the further decrease of number of these cells that were already starting to be produced in lower numbers.
As leukemia aggravates, the state of the blood also aggravates. This may become overwhelmed by immature white cells leading to severe problems in the patient, like: fatigue and weakness. The actual fact is that deprived of red cells and platelets the blood is no longer capable of coagulating properly making every little cut dangerous; to further increase risks white blood cells can’t this way fight an intruder if this ultimately makes its way into the body.
Leukemia is not a fact to joke about, the help of doctors and the need of medical attention being very big.
By: Groshan Fabiola
Article Directory: http://www.articledashboard.com
Wednesday, March 10, 2010
Cure For Leukemia From Nature
Cure For Leukemia From Nature
By Ty Daniel
Many people are now looking for natural cures to things such as leukemia. This is becoming more and more common among those that are suffering from this disease. There are many different reasons that people have for looking for natural cures for their illnesses. Some of them are because the patient may not like the chemical treatment that the doctor is offering. There can be severe and dangerous side effects and the patient may not find it worth the risk. If this is the case then they may turn to natural treatments to help them with their battle. You should certainly have hope because there are options for those seeking a cure for leukemia from nature out there.
Medical Treatment for Leukemia
The main medical treatment for leukemia is chemotherapy. The effects of chemotherapy may be detrimental to the patient in many ways. The patient may get fatigue and feel like they don't want to get out of bed. This can lead to depression and depression is far from good when you are trying to get your body to heal. Chemotherapy can also cause nausea or vomiting this is a side effect that many people simply do not like. It can make you feel very ill and that is not always good for getting your body to want to heal either.
Another common side effect from chemotherapy treatment is that you will often times lose your hair. This is undesirable and may be something that many are not willing to deal with. With chemotherapy you may find that you lose all of you hair and then are in need of a wig just to hide the fact that your hair is missing. You may also lose a good bit of weight as well. This could mainly be the cause of the nausea and vomiting enabling you from being able to eat or even keep down any amount of food.
Natures cure for leukemia
One of the most common known cures for leukemia is vitamin A. It is said that vitamin A has had great cure rates since the studies that have been done on it. In the studies vitamin A was injected directly into the fat of the person with leukemia. This deposit of vitamin A was said to be deposited into a "fat bubble" or into "bubbles of fat" to increase or enhance bio-availability.
There were 34 patients that were in the study and all they received was the vitamin A. Out of these 34 patients that received the vitamin A, 10 of these patients where still cancer free after five years even though none of these patients received the chemotherapy treatments. This was said to be astonishing by those who preformed the study.
These patients received only vitamin A for the natural treatment they did not receive any of the other natural remedies that are proven to help with leukemia as well. There are many other herbs and vitamins that if taken in conjunction with the vitamin A are thought to increase the success rate of the vitamin A treatment.
There are other supplements that you may want to take with this cure for leukemia remedy to improve the chances of being cured even more.
Article Source: http://EzineArticles.com/?expert=Ty_Daniel
By Ty Daniel
Many people are now looking for natural cures to things such as leukemia. This is becoming more and more common among those that are suffering from this disease. There are many different reasons that people have for looking for natural cures for their illnesses. Some of them are because the patient may not like the chemical treatment that the doctor is offering. There can be severe and dangerous side effects and the patient may not find it worth the risk. If this is the case then they may turn to natural treatments to help them with their battle. You should certainly have hope because there are options for those seeking a cure for leukemia from nature out there.
Medical Treatment for Leukemia
The main medical treatment for leukemia is chemotherapy. The effects of chemotherapy may be detrimental to the patient in many ways. The patient may get fatigue and feel like they don't want to get out of bed. This can lead to depression and depression is far from good when you are trying to get your body to heal. Chemotherapy can also cause nausea or vomiting this is a side effect that many people simply do not like. It can make you feel very ill and that is not always good for getting your body to want to heal either.
Another common side effect from chemotherapy treatment is that you will often times lose your hair. This is undesirable and may be something that many are not willing to deal with. With chemotherapy you may find that you lose all of you hair and then are in need of a wig just to hide the fact that your hair is missing. You may also lose a good bit of weight as well. This could mainly be the cause of the nausea and vomiting enabling you from being able to eat or even keep down any amount of food.
Natures cure for leukemia
One of the most common known cures for leukemia is vitamin A. It is said that vitamin A has had great cure rates since the studies that have been done on it. In the studies vitamin A was injected directly into the fat of the person with leukemia. This deposit of vitamin A was said to be deposited into a "fat bubble" or into "bubbles of fat" to increase or enhance bio-availability.
There were 34 patients that were in the study and all they received was the vitamin A. Out of these 34 patients that received the vitamin A, 10 of these patients where still cancer free after five years even though none of these patients received the chemotherapy treatments. This was said to be astonishing by those who preformed the study.
These patients received only vitamin A for the natural treatment they did not receive any of the other natural remedies that are proven to help with leukemia as well. There are many other herbs and vitamins that if taken in conjunction with the vitamin A are thought to increase the success rate of the vitamin A treatment.
There are other supplements that you may want to take with this cure for leukemia remedy to improve the chances of being cured even more.
Article Source: http://EzineArticles.com/?expert=Ty_Daniel
Monday, December 14, 2009
Leukemia Cure - Survival Rates Of Patients With Leukemia
Leukemia Cure - Survival Rates Of Patients With Leukemia
Although medical science has evolved significantly in the last decades, the treatment of leukemia is still a major issue in present. Modern medicine doesn’t hold the cure for leukemia and medical treatments available these days provide differentiated results. Survival rates depend on the promptitude of diagnosis, the type of treatment and the patients’ responsiveness to specific cancer therapies and treatments.
Although leukemia can’t always be completely overcome, the progression of the disease can be slowed down and its malignant effects can be contained with the help of existent cancer treatments. Thus, the life expectancy of patients with leukemia has risen considerably in the last three decades. By contrast, the mortality rate registered among patients with leukemia has known a pronounced decrease in the last decade.
The treatment of leukemia is focused towards achieving a complete remission with minimal side-effects. Complete remission refers to absence of leukemia traces at cellular level. Patients who present no evidence of malignant cellular activity after completing the treatment of leukemia are considered to be completely cured. By contrast, relapse indicates a recurrence of leukemia specific symptoms and physiological signs.
In the case of patients with acute leukemia, a remission that lasts for more than five years after the treatment suggests a complete recovery. This five-year period is considered to be critical for leukemia sufferers, as it can make the difference between relapse and complete recovery.
In the last few decades, the five-year survival period of patients with leukemia has tripled. While in the 60’s the five-year survival rate was around 15 percent, nowadays it revolves around 50 percent. This five-year survival period is strongly influenced by patients’ age and the type of leukemia. Statistics indicate that the five-year survival rate for patients with acute lymphocytic leukemia (ALL) is around 60 percent, while the five-year survival rate for patients with chronic lymphocytic leukemia (CLL) is higher, reaching the value of 70 percent. By contrast, the prognosis of patients with myelogenous leukemia is less favorable. The same five-year survival rate for patients diagnosed with acute myelogenous leukemia (AML) is around 14 percent, while an estimated 32 percent of patients with chronic myelogenous leukemia (CML) exceed this five-year survival period.
The five-year survival rate for children diagnosed with acute lymphocytic leukemia revolves around the value of 80 percent, while the overall survival rate of children with acute lymphocytic leukemia is less than 45 percent. This type of leukemia is the most common form of cancer diagnosed in children. Due to the fact that it predominantly affects young patients with ages between 3 and 15, the disease is referred to as childhood leukemia.
In the United States, the mortality rate for children with leukemia has decreased with 60 percent in the last three decades. In spite of this fact, leukemia is still the leading cause of death among young patients with ages under 15.
Although medical science has evolved significantly in the last decades, the treatment of leukemia is still a major issue in present. Modern medicine doesn’t hold the cure for leukemia and medical treatments available these days provide differentiated results. Survival rates depend on the promptitude of diagnosis, the type of treatment and the patients’ responsiveness to specific cancer therapies and treatments.
Although leukemia can’t always be completely overcome, the progression of the disease can be slowed down and its malignant effects can be contained with the help of existent cancer treatments. Thus, the life expectancy of patients with leukemia has risen considerably in the last three decades. By contrast, the mortality rate registered among patients with leukemia has known a pronounced decrease in the last decade.
The treatment of leukemia is focused towards achieving a complete remission with minimal side-effects. Complete remission refers to absence of leukemia traces at cellular level. Patients who present no evidence of malignant cellular activity after completing the treatment of leukemia are considered to be completely cured. By contrast, relapse indicates a recurrence of leukemia specific symptoms and physiological signs.
In the case of patients with acute leukemia, a remission that lasts for more than five years after the treatment suggests a complete recovery. This five-year period is considered to be critical for leukemia sufferers, as it can make the difference between relapse and complete recovery.
In the last few decades, the five-year survival period of patients with leukemia has tripled. While in the 60’s the five-year survival rate was around 15 percent, nowadays it revolves around 50 percent. This five-year survival period is strongly influenced by patients’ age and the type of leukemia. Statistics indicate that the five-year survival rate for patients with acute lymphocytic leukemia (ALL) is around 60 percent, while the five-year survival rate for patients with chronic lymphocytic leukemia (CLL) is higher, reaching the value of 70 percent. By contrast, the prognosis of patients with myelogenous leukemia is less favorable. The same five-year survival rate for patients diagnosed with acute myelogenous leukemia (AML) is around 14 percent, while an estimated 32 percent of patients with chronic myelogenous leukemia (CML) exceed this five-year survival period.
The five-year survival rate for children diagnosed with acute lymphocytic leukemia revolves around the value of 80 percent, while the overall survival rate of children with acute lymphocytic leukemia is less than 45 percent. This type of leukemia is the most common form of cancer diagnosed in children. Due to the fact that it predominantly affects young patients with ages between 3 and 15, the disease is referred to as childhood leukemia.
In the United States, the mortality rate for children with leukemia has decreased with 60 percent in the last three decades. In spite of this fact, leukemia is still the leading cause of death among young patients with ages under 15.
By: Muscle Trainer
Article Directory: http://www.articledashboard.com
Wednesday, August 12, 2009
Tests For Determining Leukemia
Tests For Determining Leukemia
The stem cells are formed by the leukemia cells in the bone marrow.These cells have uncontrolled growth and lead to decrease production of normal blood cells.From this point of view the symptoms are:anemia, increased risk of bleeding which include bleeding gums, nosebleeds, bruising, increased risk of infection, slow healing.
The common symptoms of leukemia are:fatigue, lack of appetite, weight loss, fever,sweating.When leukemia arrives to the thymus gland the possible symptoms are:coughing or shortness of breath when the trachea is pressed by the enlarged thymus and swelling of the head and arms (SVC syndrome) when the superior vena cava is pressed by the enlarged thymus.
In the case when the leukemia spreads to the central nervous system there are other possible symptoms like: headaches, poor school performance, weakness, seizures, vomiting, poor balance, blurred vision.Other potential symptoms are: enlargement of the liver and spleen, enlargement of the lymph nodes,enlargement of the testicles and bone or joint pain.
The symptoms of acute myelogenous leukemia are gingivitis and rash.The blood tests demanded for the leukemia diagnosis are: low red blood cell count, low platelets count, high white blood cell count, presence of white blood cell blasts.If blood tests shows leukemia presence, additional cells for analysis are obtained from the : bone marrow named bone marrow biopsy, lymph nodes named lymph node excision and cerebrospinal fluid named spinal tap.
To classify leukemia are used the following techniques: microscopic analysis of cell size and shape, cytochemistry-microscopic analysis of cell after treatment with chemicals, immunocytochemistry of flow cytometry-analysis of cells after treatment with laboratory antibodies, cytogenetics-analysis of the chromosomes in leukemia cells and molecular genetics-analysis of specific DNA sequences in leukemia cells.
When a child is diagnosed with leukemia the tests to be performed are the following: a chest x-ray for determine leukemia masses in the chest, bone x-rays for determine leukemia invasion of the bones or joints, a CT Scan for determine leukemia in certain lymph nodes and an MRI for determine leukemia in the brain.After the leukemia has been diagnosed additional tests can give informational about: the type of leukemia, the characteristics of the leukemia cells and its evolution through the body.
Acute lymphocytic leukemia in most cases is present to children and is indicated by two types: high-risk or low-risk.Patients with low-risk respond better to treatment with the possibility of curding, and patients with high-risk respond also to treatment but receive a more intensive treatment.Even if leukemia represents the blood cancer nowadays it can be treated due to the science evolution.
The stem cells are formed by the leukemia cells in the bone marrow.These cells have uncontrolled growth and lead to decrease production of normal blood cells.From this point of view the symptoms are:anemia, increased risk of bleeding which include bleeding gums, nosebleeds, bruising, increased risk of infection, slow healing.
The common symptoms of leukemia are:fatigue, lack of appetite, weight loss, fever,sweating.When leukemia arrives to the thymus gland the possible symptoms are:coughing or shortness of breath when the trachea is pressed by the enlarged thymus and swelling of the head and arms (SVC syndrome) when the superior vena cava is pressed by the enlarged thymus.
In the case when the leukemia spreads to the central nervous system there are other possible symptoms like: headaches, poor school performance, weakness, seizures, vomiting, poor balance, blurred vision.Other potential symptoms are: enlargement of the liver and spleen, enlargement of the lymph nodes,enlargement of the testicles and bone or joint pain.
The symptoms of acute myelogenous leukemia are gingivitis and rash.The blood tests demanded for the leukemia diagnosis are: low red blood cell count, low platelets count, high white blood cell count, presence of white blood cell blasts.If blood tests shows leukemia presence, additional cells for analysis are obtained from the : bone marrow named bone marrow biopsy, lymph nodes named lymph node excision and cerebrospinal fluid named spinal tap.
To classify leukemia are used the following techniques: microscopic analysis of cell size and shape, cytochemistry-microscopic analysis of cell after treatment with chemicals, immunocytochemistry of flow cytometry-analysis of cells after treatment with laboratory antibodies, cytogenetics-analysis of the chromosomes in leukemia cells and molecular genetics-analysis of specific DNA sequences in leukemia cells.
When a child is diagnosed with leukemia the tests to be performed are the following: a chest x-ray for determine leukemia masses in the chest, bone x-rays for determine leukemia invasion of the bones or joints, a CT Scan for determine leukemia in certain lymph nodes and an MRI for determine leukemia in the brain.After the leukemia has been diagnosed additional tests can give informational about: the type of leukemia, the characteristics of the leukemia cells and its evolution through the body.
Acute lymphocytic leukemia in most cases is present to children and is indicated by two types: high-risk or low-risk.Patients with low-risk respond better to treatment with the possibility of curding, and patients with high-risk respond also to treatment but receive a more intensive treatment.Even if leukemia represents the blood cancer nowadays it can be treated due to the science evolution.
By: Groshan Fabiola
Article Directory: http://www.articledashboard.com
Monday, June 8, 2009
Complete Information On Chronic Myelogenous Leukemia
Complete Information On Chronic Myelogenous Leukemia
Chronic myeloid leukemia (CML), too known as chronic myelogenous leukemia. Chronic myelogenous leukemia (CML) is a slow-growing cancer of the light-colored blood cells. It is too sometimes called chronic myeloid, chronic granulocytic or chronic myelocytic leukemia.
CML is a popular leukemia. In the United States, much than 20,000 folk have CML and about 4,600 original cases are diagnosed each year. Most cases of CML seem in adults, but about 2 to 4% of CML patients are children. CML is an acquired irregularity that involves the hematopoietic stalk cubicle.
It is characterized by a cytogenetic aberration consisting of a reciprocal translocation between the long arms of chromosomes 22. The translocation results in a shortened chromosome 22, an observation first described by Nowell and Hungerford and subsequently termed the Philadelphia (Ph) chromosome after the city of discovery. Early signs and symptoms of CML are often vague.
They may include fever , losing weight without trying , loss of appetite and Feeling run-down or tired , pain or fullness below the ribs on the left side and sweating excessively during sleep (night sweats). Chronic myelogenous leukemia is a rare form of leukemia.
Chronic myelogenous leukemia is affecting simply one to two of every 100,000 people. Exposure to really higher levels of radioactivity increases the danger of developing chronic myelogenous leukemia the simply known danger element for this character of cancer. Survivors of a nuclear bomb attack or an atomic reactor accident are at high danger of developing chronic myelogenous leukemia.
The better handling will be distinct for distinct patients, depending on a patient's age and new health factors. Treatment normally consists of respective chemotherapeutic agents used to interrupt the output of leukemic cells.
These treatments may be followed by stalk cubicle transplantation. A marrow or incidental blood cubicle transplantation using cells from a household member or unconnected giver (an allogeneic transplantation) is the simply known handling that can heal CML.
A transplantation replaces the irregular cells in the patient's ivory marrow with robust cells from a giver. Autologous transplantation (using the patient's own cells) is being studied as a handling for CML that returns after Gleevec handling. Bone marrow transplant was too used as initial handling for CML in younger patients before the coming of imatinib.
Chronic myeloid leukemia (CML), too known as chronic myelogenous leukemia. Chronic myelogenous leukemia (CML) is a slow-growing cancer of the light-colored blood cells. It is too sometimes called chronic myeloid, chronic granulocytic or chronic myelocytic leukemia.
CML is a popular leukemia. In the United States, much than 20,000 folk have CML and about 4,600 original cases are diagnosed each year. Most cases of CML seem in adults, but about 2 to 4% of CML patients are children. CML is an acquired irregularity that involves the hematopoietic stalk cubicle.
It is characterized by a cytogenetic aberration consisting of a reciprocal translocation between the long arms of chromosomes 22. The translocation results in a shortened chromosome 22, an observation first described by Nowell and Hungerford and subsequently termed the Philadelphia (Ph) chromosome after the city of discovery. Early signs and symptoms of CML are often vague.
They may include fever , losing weight without trying , loss of appetite and Feeling run-down or tired , pain or fullness below the ribs on the left side and sweating excessively during sleep (night sweats). Chronic myelogenous leukemia is a rare form of leukemia.
Chronic myelogenous leukemia is affecting simply one to two of every 100,000 people. Exposure to really higher levels of radioactivity increases the danger of developing chronic myelogenous leukemia the simply known danger element for this character of cancer. Survivors of a nuclear bomb attack or an atomic reactor accident are at high danger of developing chronic myelogenous leukemia.
The better handling will be distinct for distinct patients, depending on a patient's age and new health factors. Treatment normally consists of respective chemotherapeutic agents used to interrupt the output of leukemic cells.
These treatments may be followed by stalk cubicle transplantation. A marrow or incidental blood cubicle transplantation using cells from a household member or unconnected giver (an allogeneic transplantation) is the simply known handling that can heal CML.
A transplantation replaces the irregular cells in the patient's ivory marrow with robust cells from a giver. Autologous transplantation (using the patient's own cells) is being studied as a handling for CML that returns after Gleevec handling. Bone marrow transplant was too used as initial handling for CML in younger patients before the coming of imatinib.
By: Juliet Cohen
Article Directory: http://www.articledashboard.com
Monday, May 18, 2009
Childhood Leukaemia And Various Subtypes
Childhood Leukaemia And Various Subtypes
Although there are no accurate data for concordance rates of leukaemia in infant twins, it seems to be very high, and perhaps approaching one hundred percents. If this is correct, it suggests that MLL gene fusion in utero has a dramatic impact, ensuring subsequent leukaemia. But for children aged between two and six years who have acute lymphoblastic leukaemia, the concordance rate is considerably lower at around five percents.
This still represents a one hundred fold extra risk of leukaemia for the twin of a patient with acute lymphoblastic leukaemia but also indicates the need for some additional postnatal events for which there is a one in twenty chance, or ninety five percent discordance. This actually suggests, at a minimum, a two hit model for the natural course of childhood leukaemia.
If this model of leukaemia development is correct, then for every child with acute lymphoblastic leukaemia diagnosed, there should be at least twenty healthy children who actually have had a chromosome translocation, a functional leukaemia fusion gene, and a covert pre leukemic clone generated in utero.
This possibility has been investigated by screening unselected samples of newborn cord blood for fusion genes. Cord blood is actually the best place to find stem cells especially if you want to do umbilical cord blood collection and then go to a cord blood bank or stem cell bank to store it just in case.
The real bottleneck in development of acute lymphoblastic leukaemia therefore seems to be a stringent requirement for a second hit after birth, which is exposure and additional chromosomal or molecular abnormality.
A key issue to resolve is what exposures or events might precipitate the chromosome breaks whose improper repair initiates or promotes childhood leukaemia. Given the biological diversity of leukaemia, it is highly unlikely that there is a single cause. Even for a defined biological subtype of the disease, there probably is not one cause as such but a causal mechanism. As with other cancers, this is likely to involve an interaction of exposure with inherent genetic susceptibility, and chance.
Epidemiological evidence suggests that ionising radiation, certain chemicals, viruses and bacteria may actually play a part in the development of some subtypes of leukaemia and lymphoma in adults and children. Whether any of these exposures have a major role in childhood leukaemia is uncertain, but large scale case control molecular epidemiological studies in Great Britain and the United States if America may provide answers. Doing stem cell storage or cord blood storage in a cord blood bank or a stem cell bank could be a good solution as breakthrough seems to happen more and more often.
Although there are no accurate data for concordance rates of leukaemia in infant twins, it seems to be very high, and perhaps approaching one hundred percents. If this is correct, it suggests that MLL gene fusion in utero has a dramatic impact, ensuring subsequent leukaemia. But for children aged between two and six years who have acute lymphoblastic leukaemia, the concordance rate is considerably lower at around five percents.
This still represents a one hundred fold extra risk of leukaemia for the twin of a patient with acute lymphoblastic leukaemia but also indicates the need for some additional postnatal events for which there is a one in twenty chance, or ninety five percent discordance. This actually suggests, at a minimum, a two hit model for the natural course of childhood leukaemia.
If this model of leukaemia development is correct, then for every child with acute lymphoblastic leukaemia diagnosed, there should be at least twenty healthy children who actually have had a chromosome translocation, a functional leukaemia fusion gene, and a covert pre leukemic clone generated in utero.
This possibility has been investigated by screening unselected samples of newborn cord blood for fusion genes. Cord blood is actually the best place to find stem cells especially if you want to do umbilical cord blood collection and then go to a cord blood bank or stem cell bank to store it just in case.
The real bottleneck in development of acute lymphoblastic leukaemia therefore seems to be a stringent requirement for a second hit after birth, which is exposure and additional chromosomal or molecular abnormality.
A key issue to resolve is what exposures or events might precipitate the chromosome breaks whose improper repair initiates or promotes childhood leukaemia. Given the biological diversity of leukaemia, it is highly unlikely that there is a single cause. Even for a defined biological subtype of the disease, there probably is not one cause as such but a causal mechanism. As with other cancers, this is likely to involve an interaction of exposure with inherent genetic susceptibility, and chance.
Epidemiological evidence suggests that ionising radiation, certain chemicals, viruses and bacteria may actually play a part in the development of some subtypes of leukaemia and lymphoma in adults and children. Whether any of these exposures have a major role in childhood leukaemia is uncertain, but large scale case control molecular epidemiological studies in Great Britain and the United States if America may provide answers. Doing stem cell storage or cord blood storage in a cord blood bank or a stem cell bank could be a good solution as breakthrough seems to happen more and more often.
By: Wayne Cha
Article Directory: http://www.articledashboard.com
Thursday, May 7, 2009
Some Facts About Leukemia Treatment Options
Some Facts About Leukemia Treatment Options
Leukemia has two major types: acute and chronic. In what concerns acute leukemia, there are two forms: if leukemia involves lymphocytes, we are dealing with acute lymphoblastic leukemia, and if it involves myeloid cells, is called acute myelogenous leukemia. Depending on the particular cell that has become malignant, there can be many different types of acute lymphoblastic leukemia and acute myelogenous leukemia.It was seen that chronic leukemia affects primarily the myeloid cells in the bone marrow.
This is called chronic myelogenous leukemia, and is found mostly in adults, but children and teenagers can develop it too.We must mention that there exists a disorder of the bone marrow known as myelodysplastic syndrome. Often called a pre-leukemia syndrome because patients with it have a significantly increased risk of developing leukemia, this syndrome is often associated with low blood cell counts and increased requirements for transfusions.
Allogeneic bone marrow stem cell transplantation is used to treat a variety of childhood leukemias or cancers and myelodysplastic syndrome that involve the cells within the bone marrow. In this transplant, there are used another person's bone marrow cells to restore bone marrow after high dose chemotherapy and radiation therapy.As an advantage of an allogeneic transplant over an autologous transplant we can mention the "graft-versus-leukemia effect".
The donor’s healthy bone marrow kills residual leukemia cells, and in this way decreases the patient's chance of relapse.As a disadvantage of an allogeneic bone marrow stem cell transplant we can mention the risk of graft-versus-host disease. This happens when the other person's bone marrow attacks the recipient's body. In this way, there appears a disease that affects the skin, liver and many other organs. In this case, therapy with immunosuppressive drugs is needed.
When a matched donor is available, there can be performed transplantation for high-risk leukemia patients in first remission. In very high-risk patients, like those with leukemia who fail to achieve first remission with chemotherapy, there can be done an unrelated donor transplant as soon as remission is achieved. As eligible we can mention infants with leukemia, children with high-risk lymphoblastic leukemia and children with acute myelogenous leukemia. Also, children with myelodysplastic syndrome are eligible for transplant as soon as the diagnosis is established.
Many children with acute leukemias whose leukemia has relapsed can have bone marrow stem cell transplantation. Transplantation can be from related donors like brothers, sisters, parents, and occasionally more distant relatives such as cousins and grandparents.Also, transplantation can be from matched unrelated donors, including umbilical cord blood.In what concerns children with chronic myelogenous leukemia who cannot be put into complete remission with drugs, they should undergo a transplant as early as possible in the course of the disease.
Leukemia has two major types: acute and chronic. In what concerns acute leukemia, there are two forms: if leukemia involves lymphocytes, we are dealing with acute lymphoblastic leukemia, and if it involves myeloid cells, is called acute myelogenous leukemia. Depending on the particular cell that has become malignant, there can be many different types of acute lymphoblastic leukemia and acute myelogenous leukemia.It was seen that chronic leukemia affects primarily the myeloid cells in the bone marrow.
This is called chronic myelogenous leukemia, and is found mostly in adults, but children and teenagers can develop it too.We must mention that there exists a disorder of the bone marrow known as myelodysplastic syndrome. Often called a pre-leukemia syndrome because patients with it have a significantly increased risk of developing leukemia, this syndrome is often associated with low blood cell counts and increased requirements for transfusions.
Allogeneic bone marrow stem cell transplantation is used to treat a variety of childhood leukemias or cancers and myelodysplastic syndrome that involve the cells within the bone marrow. In this transplant, there are used another person's bone marrow cells to restore bone marrow after high dose chemotherapy and radiation therapy.As an advantage of an allogeneic transplant over an autologous transplant we can mention the "graft-versus-leukemia effect".
The donor’s healthy bone marrow kills residual leukemia cells, and in this way decreases the patient's chance of relapse.As a disadvantage of an allogeneic bone marrow stem cell transplant we can mention the risk of graft-versus-host disease. This happens when the other person's bone marrow attacks the recipient's body. In this way, there appears a disease that affects the skin, liver and many other organs. In this case, therapy with immunosuppressive drugs is needed.
When a matched donor is available, there can be performed transplantation for high-risk leukemia patients in first remission. In very high-risk patients, like those with leukemia who fail to achieve first remission with chemotherapy, there can be done an unrelated donor transplant as soon as remission is achieved. As eligible we can mention infants with leukemia, children with high-risk lymphoblastic leukemia and children with acute myelogenous leukemia. Also, children with myelodysplastic syndrome are eligible for transplant as soon as the diagnosis is established.
Many children with acute leukemias whose leukemia has relapsed can have bone marrow stem cell transplantation. Transplantation can be from related donors like brothers, sisters, parents, and occasionally more distant relatives such as cousins and grandparents.Also, transplantation can be from matched unrelated donors, including umbilical cord blood.In what concerns children with chronic myelogenous leukemia who cannot be put into complete remission with drugs, they should undergo a transplant as early as possible in the course of the disease.
By: Groshan Fabiola
Article Directory: http://www.articledashboard.com
Wednesday, April 22, 2009
Childhood Leukemia And Various Subtypes
Childhood Leukemia And Various Subtypes
Although there are no accurate data for concordance rates of leukemia in infant twins, it seems to be very high, and perhaps approaching one hundred percents. If this is correct, it suggests that MLL gene fusion in utero has a dramatic impact, ensuring subsequent leukemia. But for children aged between two and six years who have acute lymphoblastic leukemia, the concordance rate is considerably lower at around five percents.
This still represents a one hundred fold extra risk of leukemia for the twin of a patient with acute lymphoblastic leukaemia but also indicates the need for some additional postnatal events for which there is a one in twenty chance, or ninety five percent discordance. This actually suggests, at a minimum, a two hit model for the natural course of childhood leukemia.
If this model of leukemia development is correct, then for every child with acute lymphoblastic leukemia diagnosed, there should be at least twenty healthy children who actually have had a chromosome translocation, a functional leukemia fusion gene, and a covert pre leukemic clone generated in utero.
This possibility has been investigated by screening unselected samples of newborn cord blood for fusion genes. Cord blood is actually the best place to find stem cells especially if you want to do umbilical cord blood collection and then go to a cord blood bank or stem cell bank to store it just in case.
The real bottleneck in development of acute lymphoblastic leukemia therefore seems to be a stringent requirement for a second hit after birth, which is exposure and additional chromosomal or molecular abnormality.
A key issue to resolve is what exposures or events might precipitate the chromosome breaks whose improper repair initiates or promotes childhood leukemia. Given the biological diversity of leukemia, it is highly unlikely that there is a single cause. Even for a defined biological subtype of the disease, there probably is not one cause as such but a causal mechanism.
As with other cancers, this is likely to involve an interaction of exposure with inherent genetic susceptibility, and chance.
Epidemiological evidence suggests that ionising radiation, certain chemicals, viruses and bacteria may actually play a part in the development of some subtypes of leukemia and lymphoma in adults and children.
Whether any of these exposures have a major role in childhood leukemia is uncertain, but large scale case control molecular epidemiological studies in Great Britain and the United States if America may provide answers. Doing stem cell storage or cord blood storage in a cord blood bank or a stem cell bank could be a good solution as breakthrough seems to happen more and more often.
By: Wayne Cha
Article Directory: http://www.articledashboard.com
Although there are no accurate data for concordance rates of leukemia in infant twins, it seems to be very high, and perhaps approaching one hundred percents. If this is correct, it suggests that MLL gene fusion in utero has a dramatic impact, ensuring subsequent leukemia. But for children aged between two and six years who have acute lymphoblastic leukemia, the concordance rate is considerably lower at around five percents.
This still represents a one hundred fold extra risk of leukemia for the twin of a patient with acute lymphoblastic leukaemia but also indicates the need for some additional postnatal events for which there is a one in twenty chance, or ninety five percent discordance. This actually suggests, at a minimum, a two hit model for the natural course of childhood leukemia.
If this model of leukemia development is correct, then for every child with acute lymphoblastic leukemia diagnosed, there should be at least twenty healthy children who actually have had a chromosome translocation, a functional leukemia fusion gene, and a covert pre leukemic clone generated in utero.
This possibility has been investigated by screening unselected samples of newborn cord blood for fusion genes. Cord blood is actually the best place to find stem cells especially if you want to do umbilical cord blood collection and then go to a cord blood bank or stem cell bank to store it just in case.
The real bottleneck in development of acute lymphoblastic leukemia therefore seems to be a stringent requirement for a second hit after birth, which is exposure and additional chromosomal or molecular abnormality.
A key issue to resolve is what exposures or events might precipitate the chromosome breaks whose improper repair initiates or promotes childhood leukemia. Given the biological diversity of leukemia, it is highly unlikely that there is a single cause. Even for a defined biological subtype of the disease, there probably is not one cause as such but a causal mechanism.
As with other cancers, this is likely to involve an interaction of exposure with inherent genetic susceptibility, and chance.
Epidemiological evidence suggests that ionising radiation, certain chemicals, viruses and bacteria may actually play a part in the development of some subtypes of leukemia and lymphoma in adults and children.
Whether any of these exposures have a major role in childhood leukemia is uncertain, but large scale case control molecular epidemiological studies in Great Britain and the United States if America may provide answers. Doing stem cell storage or cord blood storage in a cord blood bank or a stem cell bank could be a good solution as breakthrough seems to happen more and more often.
By: Wayne Cha
Article Directory: http://www.articledashboard.com
Friday, April 10, 2009
Treatment Of Leukemia
Treatment Of Leukemia
Leukemia is a type of cancer that affects the blood and bone marrow. There are two types of leukemia, chronic and acute, which are treated differently and have different symptoms. Acute leukemia rapidly progresses and needs immediate, aggressive treatment. Chronic leukemia can take months or years to show symptoms and may not need immediate treatment but will require ongoing monitoring.
The most efficient treatment is the injection of healthy cells from a compatible donor inside the bone marrow. It has the highest chances of curing the patients but also the most many side-effects. The second therapy method is the targeted therapy with Gleevec but its curative potential is not yet well established as it has been available only since 2001. A treatment way with benefic results until this time is the immune sustaining Interferon. Other possible cures are in course of development but are not yet approved.
Prognosis for Acute Leukemia
Untreated, acute leukemia is usually fatal, often because of complications that result from leukemic cells infiltrating into the bone marrow or vital body organs.
With treatment prognosis varies, survival rates in leukemia have risen dramatically in the last 40 years with improvements in diagnosis and treatment. Children between 2 and 8 have the best survival rate (around 50%) but overall, treatment does induce remission in about 90% of cases.
To kill all cancerous cells the patient follows a treatment with a very high dose of chemotherapy and radiation.All normal bone marrow cells are killed due to the does of chemotherapy and radiation.Then the bone marrow is repopulated by the stored stem cells which return to the body.To treat disease and also to maintain the immunity of the body immunotherapy is used.For the patients with leukemia interferon alfa which is an immune-system activator produced as a drug for bolstering the immune system of the body is successfully used.
Green Tea has been shown to prevent cancer - Green tea’s anti-oxidants have been shown to have cancer preventative effects. Anti-oxidants neutralize free radicals, the damaging molecules that are created as a by-product of our digestion process. Without the proper level of anti-oxidants in our diets, these free radicals can cause aging and disease, including cancer. Many foods, mostly fruits and vegetables, contain anti-oxidants; but green tea has some of the most potent available.
Some patients do not survive the treatment, but the number of victims is decreasing as years pass, and we can only hope that an effective cure will be found in the near future.
Sweating is a powerful way to cleanse the body from accumulated toxins that usually cause leukemia. In addition to this bowel cleansing, dental cleanup, kidney cleansing and liver cleansing also contribute to preventing leukemia. Other ways of reducing the risk are prevention of maternal smoking, paternal heavy drinking, use of anti nausea drugs during pregnancy, and exposure to solvents or absorption of contaminated water. However, it should be noted that the above-mentioned preventions are mere suggestions. Since the accurate factors that cause leukemia are unknown, prevention for the same remains a general hypothesis.
By: Scott Gillespie
Article Directory: http://www.articledashboard.com
Leukemia is a type of cancer that affects the blood and bone marrow. There are two types of leukemia, chronic and acute, which are treated differently and have different symptoms. Acute leukemia rapidly progresses and needs immediate, aggressive treatment. Chronic leukemia can take months or years to show symptoms and may not need immediate treatment but will require ongoing monitoring.
The most efficient treatment is the injection of healthy cells from a compatible donor inside the bone marrow. It has the highest chances of curing the patients but also the most many side-effects. The second therapy method is the targeted therapy with Gleevec but its curative potential is not yet well established as it has been available only since 2001. A treatment way with benefic results until this time is the immune sustaining Interferon. Other possible cures are in course of development but are not yet approved.
Prognosis for Acute Leukemia
Untreated, acute leukemia is usually fatal, often because of complications that result from leukemic cells infiltrating into the bone marrow or vital body organs.
With treatment prognosis varies, survival rates in leukemia have risen dramatically in the last 40 years with improvements in diagnosis and treatment. Children between 2 and 8 have the best survival rate (around 50%) but overall, treatment does induce remission in about 90% of cases.
To kill all cancerous cells the patient follows a treatment with a very high dose of chemotherapy and radiation.All normal bone marrow cells are killed due to the does of chemotherapy and radiation.Then the bone marrow is repopulated by the stored stem cells which return to the body.To treat disease and also to maintain the immunity of the body immunotherapy is used.For the patients with leukemia interferon alfa which is an immune-system activator produced as a drug for bolstering the immune system of the body is successfully used.
Green Tea has been shown to prevent cancer - Green tea’s anti-oxidants have been shown to have cancer preventative effects. Anti-oxidants neutralize free radicals, the damaging molecules that are created as a by-product of our digestion process. Without the proper level of anti-oxidants in our diets, these free radicals can cause aging and disease, including cancer. Many foods, mostly fruits and vegetables, contain anti-oxidants; but green tea has some of the most potent available.
Some patients do not survive the treatment, but the number of victims is decreasing as years pass, and we can only hope that an effective cure will be found in the near future.
Sweating is a powerful way to cleanse the body from accumulated toxins that usually cause leukemia. In addition to this bowel cleansing, dental cleanup, kidney cleansing and liver cleansing also contribute to preventing leukemia. Other ways of reducing the risk are prevention of maternal smoking, paternal heavy drinking, use of anti nausea drugs during pregnancy, and exposure to solvents or absorption of contaminated water. However, it should be noted that the above-mentioned preventions are mere suggestions. Since the accurate factors that cause leukemia are unknown, prevention for the same remains a general hypothesis.
By: Scott Gillespie
Article Directory: http://www.articledashboard.com
Subscribe to:
Posts (Atom)
Google Search
Useful Link
Blog Archive
-
►
2013
(1)
- ► 06/09 - 06/16 (1)
-
►
2012
(5)
- ► 12/16 - 12/23 (1)
- ► 10/14 - 10/21 (1)
- ► 06/24 - 07/01 (1)
- ► 05/20 - 05/27 (1)
- ► 03/04 - 03/11 (1)
-
►
2011
(1)
- ► 09/18 - 09/25 (1)
-
►
2010
(5)
- ► 11/28 - 12/05 (1)
- ► 10/03 - 10/10 (1)
- ► 08/08 - 08/15 (1)
- ► 07/04 - 07/11 (1)
- ► 03/07 - 03/14 (1)
-
►
2009
(13)
- ► 12/13 - 12/20 (1)
- ► 08/09 - 08/16 (1)
- ► 06/07 - 06/14 (1)
- ► 05/17 - 05/24 (1)
- ► 05/03 - 05/10 (1)
- ► 04/19 - 04/26 (1)
- ► 04/05 - 04/12 (1)
- ► 03/15 - 03/22 (1)
- ► 02/15 - 02/22 (2)
- ► 01/04 - 01/11 (3)
-
►
2008
(14)
- ► 12/14 - 12/21 (1)
- ► 12/07 - 12/14 (13)




